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TORC1(rapamycin sensitive) is thought to be the central elementof the TOR signaling network, monitoring and integrat-ing a large set of intra- and extracellular processes andcontrolling growth, proliferation, and lifespan with ahost of complex downstream effects (Kapahi et al., 2010).TORC2 is also rapamycin sensitive, but contributes to thefull activation of AKT, an upstream and critical signalerof TORC1; it also mediates spatial control of cell growthby regulating the actin cytoskeleton (Hall, 2008) anddisruption of TORC2 by rapalogs appears to drive the“paradoxical” insulin resistance seen in chronic admin-istration (Lamming et al., 2012). Artificial or“surgical” menopause occurs if the ovaries areremoved or made nonfunctional by radiationtherapy. However, two of the studies showed significantlylower rates of CDD among the probiotic recipients. Certain treatments may predominate,but they coexist with lesser-used alternatives

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